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KMID : 0616619970030010157
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Journal of Soonchunhyang Medical College
1997 Volume.3 No. 1 p.157 ~ p.166
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A Study for Expression of p53 and PCNA in Lung Carcinoma
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Abstract
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To observe the expression of p53 protein and PCNA in lung carcinomas and to evaluate the correlationship between the two results, the author has been carried out immunohistochemical staining with mononuclear antibodies against p53 and PCNA. 64 cases of lung carcinomas used consist of 32 cases of squamous cell carcinomas, 18 cases of adenocarcinomas and 14 cases of small cell carcinomas, respectively.
1. p53 protein expression was seen in 16 cases out of 32 (50%) in squamous cell carcinoma, 7 cases out of 18 (39%) in adenocarcinoma and 10 cases out of 14 (71%) in small cell carcinoma.
The positive rate of p53 is highest in small cell carcinoma.
2. p53 staining degrees showed that 3+ in 75% of squamous cell carcinoma, 1+ in 58% of adenocarcinoma and 1+ in 50% in small cell carcinma. were observed.
The tumor cell composing of squamous cell carcinoma showed most strong staining to p53 protien.
3. PCNA labelling index showed higher index in p53(+) cases than p53(-) cases.
The PCNA index of squamous cell carcinoma was highest and adenocarcinoma and small cell carcinoma in order.
Above findings suggested that the PCNA index was related to p53 protein in tumor cells, but the PCNA index appeared to be influenced by the p53 protein content in tumor cells than whether the p53 protien was or not.
So the growth rate of squamous cell carcinoma appeared to be most rapid than adenocarcinoma and small cell carcinoma.
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